investigation of the effects of bisphenol a on the histology and ultrastructure of prostate and seminal vesicle glands in rats

results the main pathological finding observed in the prostrate and seminal vesicle glands, using light microscope, revealed congestion in the connective tissue and vacuolization in the secretory units of epithelial cells and epithelium rupture at 50 and 100 µg/kg doses of bpa. ultrastructure study showed vacuolization of mitochondria, condensation of nuclei and disappearance of nucleus in the prostate tissue. pathological changes showed the vacuolization and dilation of endoplamic reticulum (er) and secretory glands and disappearance of microvilli. they also showed an increase in collagen fibers around the cells in the seminal vesicle tissue in the treatment group that received 100 µg/kg bw bpa. conclusions this study revealed that bpa has adverse effects on the reproductive system in male rats. the results also revealed that bpa has destructive effects on the prostate and seminal vesicle glands. background bisphenol a is a xenoestrogen, synthesized in large quantities for the production of polymers (polycarbonates, epoxy resins) and thermal paper, and is widely used in products of everyday use (packaging, containers and bottles). data concerning the occurrence of bpa in food, water and indoor environments as well as its appearance in tissues and body fluids of the human body are available in the literature. male accessory sex glands are also vulnerable to environmental endocrine disruptors with adverse effects in adulthood. the developing prostate gland is particularly sensitive to estrogens and high-dose exposures during a critical developmental window results in intraepithelial prostatic neoplasia (pin) in adult rodent models. bisphenol a is also an endocrine disruptor. high levels of bpa exposure correlate with increased risk of mammary gland, brain and prostate cancers and have adverse effects on the tissues of the prostate and seminal vesicles. objectives the aim of this study was to investigate the effects of bpa doses on the histological structure and ultrastructure of prostate and seminal vesicle glands. methods forty male wistar rats were randomly divided into four groups (n = 10): a control group and three treatment groups, receiving bpa at doses of 10, 50 and 100 µg/kg. bisphenol a was administrated intraperitoneally for 15 days. as the prostate and seminal vesicle glands were dissected on the day 16, the structure and ultrastructure histological parameters were analyzed, using light and electron microscopes.